Common Polymorphisms Identified In Patients with Type 2 Diabetes Mellitus Revealed From Next-Generation Sequencing Analysis

Objective: Type 2 diabetes mellitus (T2DM) is a multifactorial genetic condition caused by the combination of genes and environmental factors. Several variations linked to T2DM have been discovered in recent investigations, particularly genome-wide association studies (GWAS). This study aimed investigate involved T2DM, focusing on NGS analysis studying basis improve diagnosis, prevention, treatment.
 Materials Methods: We selected 5 families based diagnosis at age 30 years or earlier least 3 consecutive generations for analyses.
 Results: For each participants tested thus far, mean 11 21 variants clinical significance were detected. These located different genes, which indicate these with susceptibility diabetes. WFS1 INS gene mutations present all five diabetic patients analyzed. Specifically, WFS1, KCNJ11, ABCC8, HNF1B, INS, GCKR, HNF1A PCSK1N account 25%, 13%, 8%, 7%, 6%, 6% patients, respectively.
 Conclusion: most often altered our putative alterations, according findings (25%). probands.